The current RhoGAM shortage has raised concerns among expectant parents and healthcare providers. As your midwife, I want to ensure you’re informed about what RhoGAM is, why it’s important, and what the shortage means for your pregnancy. Let’s also explore the availability of alternative products like Rhophylac and HyperRHO.
What is RhoGAM?
RhoGAM is a brand of Rh immunoglobulin, an injection given to Rh-negative individuals to prevent Rh incompatibility during pregnancy. Rh incompatibility occurs when an Rh-negative birthing parent carries an Rh-positive baby, potentially leading to complications in current or future pregnancies (ASHP) (UTSW).
How RhoGAM Works:
- Prevents Sensitization: RhoGAM prevents the birthing parent’s immune system from developing antibodies against Rh-positive blood cells that may cross into their bloodstream from the baby. This is known as sensitization.
- Protects Future Pregnancies: By preventing sensitization, RhoGAM reduces the risk of hemolytic disease in future pregnancies, a condition that can cause serious health issues for the baby (ASHP) (www.aabb.org).
When is RhoGAM Administered?
- RhoGAM is typically administered around the 28th week of pregnancy.
- It may also be given after any event where fetal blood might mix with the parent’s blood, such as miscarriage, amniocentesis, or delivery of an Rh-positive baby (UTSW) (ASHP).
Why is There a RhoGAM Shortage?
- Manufacturing Issues: The production of RhoGAM has been affected by a shortage of active ingredients and necessary maintenance at manufacturing plants. These disruptions have led to decreased availability (ASHP)(www.aabb.org).
- Increased Demand: The demand for Rh immunoglobulin products has increased due to heightened awareness and screening for Rh incompatibility, further straining supply (ASHP) (www.aabb.org).
- Supply Chain Challenges: Global supply chain issues, exacerbated by the COVID-19 pandemic, have affected the distribution of many medical products, including RhoGAM (ASHP) (www.aabb.org).
Are Rhophylac and HyperRHO Also Affected?
Rhophylac:
- Rhophylac is currently available to existing customers, with some extra supply for new customers depending on demand. However, CSL Behring, the manufacturer, plans to discontinue the 10-count packaging in August 2024, which might affect availability (ASHP) (www.aabb.org). It has also been challenging to obtain Rhophylac due to similar supply chain issues and increased demand (UTSW) (www.aabb.org).
HyperRHO S/D:
- HyperRHO S/D Full Dose is available, and Grifols, the manufacturer, is actively distributing it. However, it has also become difficult to secure consistent supplies, reflecting broader challenges in the market (ASHP)(www.aabb.org).
What Should You Do?
- Consult Your Midwife or Healthcare Provider: If you are Rh-negative, talk with me or your healthcare provider about your options to ensure you receive appropriate care and protection (www.aabb.org).
- Consider Alternatives: If RhoGAM is unavailable, we can discuss using Rhophylac or HyperRHO S/D to ensure you receive the necessary protection against Rh sensitization (ASHP) (www.aabb.org).
- Stay Informed: Stay updated on the status of the shortage and follow any new recommendations from healthcare providers and organizations (www.aabb.org).
- Referral to Other Providers: If suitable products are not available, I may refer you to a provider who can offer these medications or explore other options with you to ensure your needs are met, like the hospital or an OB/GYN practice (ASHP) (UTSW) (www.aabb.org).
By understanding the importance of RhoGAM and being aware of the current shortage, you can make informed decisions about your care. I am here to support you every step of the way and will work with you to ensure the best outcomes for you and your baby.
Just sharing the love and some info.
Your Midwife, Patricia
Love & Root Homebirth Midwifery and Apothecary 